Ontology highlight
ABSTRACT:
SUBMITTER: Pal D
PROVIDER: S-EPMC7188793 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Pal Debjani D Torres Adrian E AE Stromberg Benjamin R BR Messina Abbey L AL Dickson Andrew S AS De Kuntal K Willard Belinda B Venere Monica M Summers Matthew K MK
Cell death & disease 20200428 4
APC/C<sup>Cdh1</sup> is a ubiquitin ligase with roles in numerous diverse processes, including control of cellular proliferation and multiple aspects of the DNA damage response. Precise regulation of APC/C<sup>Cdh1</sup> activity is central to efficient cell-cycle progression and cellular homeostasis. Here, we have identified Cdh1 as a direct substrate of the replication stress checkpoint effector kinase Chk1 and demonstrate that Chk1-mediated phosphorylation of Cdh1 contributes to its recogniti ...[more]