Ontology highlight
ABSTRACT:
SUBMITTER: Pyenson NC
PROVIDER: S-EPMC5599366 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Cell host & microbe 20170817 3
CRISPR loci are a cluster of repeats separated by short "spacer" sequences derived from prokaryotic viruses and plasmids that determine the targets of the host's CRISPR-Cas immune response against its invaders. For type I and II CRISPR-Cas systems, single-nucleotide mutations in the seed or protospacer adjacent motif (PAM) of the target sequence cause immune failure and allow viral escape. This is overcome by the acquisition of multiple spacers that target the same invader. Here we show that tar ...[more]