Ontology highlight
ABSTRACT:
SUBMITTER: Flynn SM
PROVIDER: S-EPMC7190641 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Nature communications 20200429 1
Besides pro-inflammatory roles, the ancient cytokine interleukin-17 (IL-17) modulates neural circuit function. We investigate IL-17 signaling in neurons, and the extent it can alter organismal phenotypes. We combine immunoprecipitation and mass spectrometry to biochemically characterize endogenous signaling complexes that function downstream of IL-17 receptors in C. elegans neurons. We identify the paracaspase MALT-1 as a critical output of the pathway. MALT1 mediates signaling from many immune ...[more]