Ontology highlight
ABSTRACT:
SUBMITTER: Xiang G
PROVIDER: S-EPMC7192629 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Xiang Guanjue G Keller Cheryl A CA Giardine Belinda B An Lin L Li Qunhua Q Zhang Yu Y Hardison Ross C RC
Nucleic acids research 20200501 8
Quantitative comparison of epigenomic data across multiple cell types or experimental conditions is a promising way to understand the biological functions of epigenetic modifications. However, differences in sequencing depth and signal-to-noise ratios in the data from different experiments can hinder our ability to identify real biological variation from raw epigenomic data. Proper normalization is required prior to data analysis to gain meaningful insights. Most existing methods for data normal ...[more]