Ontology highlight
ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC7195432 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Wang Yi Y Luo Wu W Han Jibo J Khan Zia A ZA Fang Qilu Q Jin Yiyi Y Chen Xuemei X Zhang Yali Y Wang Meihong M Qian Jianchang J Huang Weijian W Lum Hazel H Wu Gaojun G Liang Guang G
Nature communications 20200501 1
Hyperglycemia activates toll-like receptor 4 (TLR4) to induce inflammation in diabetic cardiomyopathy (DCM). However, the mechanisms of TLR4 activation remain unclear. Here we examine the role of myeloid differentiation 2 (MD2), a co-receptor of TLR4, in high glucose (HG)- and diabetes-induced inflammatory cardiomyopathy. We show increased MD2 in heart tissues of diabetic mice and serum of human diabetic subjects. MD2 deficiency in mice inhibits TLR4 pathway activation, which correlates with red ...[more]