Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients.
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ABSTRACT:
SUBMITTER: Zhou Z
PROVIDER: S-EPMC7196896 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Publications
Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients.
Zhou Zhuo Z Ren Lili L Zhang Li L Zhong Jiaxin J Xiao Yan Y Jia Zhilong Z Guo Li L Yang Jing J Wang Chun C Jiang Shuai S Yang Donghong D Zhang Guoliang G Li Hongru H Chen Fuhui F Xu Yu Y Chen Mingwei M Gao Zhancheng Z Yang Jian J Dong Jie J Liu Bo B Zhang Xiannian X Wang Weidong W He Kunlun K Jin Qi Q Li Mingkun M Wang Jianwei J
Cell host & microbe 20200504 6
The outbreaks of 2019 novel coronavirus disease (COVID-19) caused by SARS-CoV-2 infection have posed a severe threat to global public health. It is unclear how the human immune system responds to this infection. Here, we used metatranscriptomic sequencing to profile immune signatures in the bronchoalveolar lavage fluid of eight COVID-19 cases. The expression of proinflammatory genes, especially chemokines, was markedly elevated in COVID-19 cases compared to community-acquired pneumonia patients ...[more]
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