Ontology highlight
ABSTRACT:
SUBMITTER: Conrad W
PROVIDER: S-EPMC3829391 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Conrad Willliam W Major Michael B MB Cleary Michele A MA Ferrer Marc M Roberts Brian B Marine Shane S Chung Namjin N Arthur William T WT Moon Randall T RT Berndt Jason D JD Chien Andy J AJ
F1000Research 20130531
The inability of targeted BRAF inhibitors to produce long-lasting improvement in the clinical outcome of melanoma highlights a need to identify additional approaches to inhibit melanoma growth. Recent studies have shown that activation of the Wnt/β-catenin pathway decreases tumor growth and cooperates with ERK/MAPK pathway inhibitors to promote apoptosis in melanoma. Therefore, the identification of Wnt/β-catenin regulators may advance the development of new approaches to treat this disease. In ...[more]