Ontology highlight
ABSTRACT:
SUBMITTER: Reid MS
PROVIDER: S-EPMC7200160 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Reid Michelle S MS Kern David M DM Brohawn Stephen Graf SG
eLife 20200414
Cation-chloride-cotransporters (CCCs) catalyze transport of Cl<sup>-</sup> with K<sup>+</sup> and/or Na<sup>+</sup>across cellular membranes. CCCs play roles in cellular volume regulation, neural development and function, audition, regulation of blood pressure, and renal function. CCCs are targets of clinically important drugs including loop diuretics and their disruption has been implicated in pathophysiology including epilepsy, hearing loss, and the genetic disorders Andermann, Gitelman, and B ...[more]