Ontology highlight
ABSTRACT:
SUBMITTER: Kern DM
PROVIDER: S-EPMC8772433 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Kern David M DM Sorum Ben B Mali Sonali S SS Hoel Christopher M CM Sridharan Savitha S Remis Jonathan P JP Toso Daniel B DB Kotecha Abhay A Bautista Diana M DM Brohawn Stephen G SG
Nature structural & molecular biology 20210622 7
SARS-CoV-2 ORF3a is a putative viral ion channel implicated in autophagy inhibition, inflammasome activation and apoptosis. 3a protein and anti-3a antibodies are found in infected patient tissues and plasma. Deletion of 3a in SARS-CoV-1 reduces viral titer and morbidity in mice, suggesting it could be an effective target for vaccines or therapeutics. Here, we present structures of SARS-CoV-2 3a determined by cryo-EM to 2.1-Å resolution. 3a adopts a new fold with a polar cavity that opens to the ...[more]