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Water-Soluble Fullerenol with Hydroxyl Group Dependence for Efficient Two-Photon Excited Photodynamic Inactivation of Infectious Microbes.

ABSTRACT: We successfully prepared water-soluble fullerenol [C60(OH)46] that exhibited a high singlet oxygen quantum yield and efficiently generated reactive oxygen species. Additionally, the water-soluble C60(OH)46 with a higher composition of exposed hydroxyl groups had superior two-photon stability and characteristics compared with that with a lower composition of such groups. Therefore, the prepared fullerenol can be an effective two-photon photosensitizer. The water-soluble C60(OH)46 had favorable two-photon properties. During two-photon photodynamic therapy, the water-soluble C60(OH)46 had substantial antimicrobial activity against Escherichia coli at an ultralow-energy level of 211.2?nJ?pixel-1 with 800 scans and a photoexcited wavelength of 760?nm.

SUBMITTER: Kuo WS

PROVIDER: S-EPMC7203358 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Water-Soluble Fullerenol with Hydroxyl Group Dependence for Efficient Two-Photon Excited Photodynamic Inactivation of Infectious Microbes.

Kuo Wen-Shuo WS Wang Jiu-Yao JY Chang Chia-Yuan CY Liu Jui-Chang JC Shao Yu-Ting YT Lin Yen-Sung YS So Edmund Cheung EC Wu Ping-Ching PC

Nanoscale research letters 20200506 1

We successfully prepared water-soluble fullerenol [C60(OH)46] that exhibited a high singlet oxygen quantum yield and efficiently generated reactive oxygen species. Additionally, the water-soluble C60(OH)46 with a higher composition of exposed hydroxyl groups had superior two-photon stability and characteristics compared with that with a lower composition of such groups. Therefore, the prepared fullerenol can be an effective two-photon photosensitizer. ...[more]

PMID: 32378063

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