Ontology highlight
ABSTRACT:
SUBMITTER: Anderson WD
PROVIDER: S-EPMC7203734 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Anderson Warren D WD Duarte Fabiana M FM Civelek Mete M Guertin Michael J MJ
Bioinformatics (Oxford, England) 20200501 9
<h4>Summary</h4>Nascent transcript measurements derived from run-on sequencing experiments are critical for the investigation of transcriptional mechanisms and regulatory networks. However, conventional mRNA gene annotations significantly differ from the boundaries of primary transcripts. New primary transcript annotations are needed to accurately interpret run-on data. We developed the primaryTranscriptAnnotation R package to infer the transcriptional start and termination sites of primary tran ...[more]