Ontology highlight
ABSTRACT:
SUBMITTER: Hernandez-Morales M
PROVIDER: S-EPMC7204511 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Hernández-Morales Miriam M Shang Trisha T Chen Jingjia J Han Victor V Liu Chunlei C
Cell reports 20200301 10
One approach to magnetogenetics uses radiofrequency (RF) waves to activate transient receptor potential channels (TRPV1 and TRPV4) that are coupled to cellular ferritins. The mechanisms underlying this effect are unclear and controversial. Theoretical calculations suggest that the heat produced by RF fields is likely orders of magnitude weaker than needed for channel activation. Using the FeRIC (Ferritin iron Redistribution to Ion Channels) system, we have uncovered a mechanism of activation of ...[more]