Ontology highlight
ABSTRACT:
SUBMITTER: Mo J
PROVIDER: S-EPMC7670425 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Mo Jie J Chen Jin J Zhang Bixiang B
Cell death & disease 20201116 11
FAM134B (also called JK-1, RETREG1), a member of the family with sequence similarity 134, was originally discovered as an oncogene in esophageal squamous cell carcinoma. However, its most famous function is that of an ER-phagy-regulating receptor. Over the decades, the powerful biological functions of FAM134B were gradually revealed. Overwhelming evidence indicates that its dysfunction is related to pathophysiological processes such as neuropathy, viral replication, inflammation, and cancer. Thi ...[more]