Cytogenetic subclone formation and evolution in progressive smoldering multiple myeloma.
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ABSTRACT:
SUBMITTER: Merz M
PROVIDER: S-EPMC7214236 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Publications
Cytogenetic subclone formation and evolution in progressive smoldering multiple myeloma.
Merz Maximilian M Hielscher Thomas T Schult David D Mai Elias K EK Raab Marc S MS Hillengass Jens J Seckinger Anja A Hose Dirk D Granzow Martin M Jauch Anna A Goldschmidt Hartmut H
Leukemia 20191111 4
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Project description:Smoldering myeloma is an asymptomatic plasma cell dyscrasia with a heterogeneous propensity to progress to active myeloma. In order to investigate the biology of smoldering myeloma patients with high risk of progression, we analyzed the genomic characteristics by FISH, SNP-arrays and gene expression profile of a group of patients with high-risk smoldering myeloma included in a multicenter randomized trial. Chromosomal abnormalities detected by FISH and SNP-arrays at diagnosis were not associated to risk of progression to symptomatic myeloma. However, the overexpression of four SNORD genes (SNORD25, SNORD27, SNORD30 and SNORD31) was correlated with shorter time to progression (P<0.03). When plasma cells from high-risk smoldering patients who progressed to symptomatic myeloma were sequentially analyzed, newly acquired lesions together with an increase in the proportion of plasma cells carrying a given abnormality were observed. These findings suggest that gene expression profiling is a valuable technique to identify smoldering myeloma patients with high risk of progression. (Clinical Trials NCT00443235).
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