Ontology highlight
ABSTRACT:
SUBMITTER: Molenaars M
PROVIDER: S-EPMC7214782 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Molenaars Marte M Janssens Georges E GE Williams Evan G EG Jongejan Aldo A Lan Jiayi J Rabot Sylvie S Joly Fatima F Moerland Perry D PD Schomakers Bauke V BV Lezzerini Marco M Liu Yasmine J YJ McCormick Mark A MA Kennedy Brian K BK van Weeghel Michel M van Kampen Antoine H C AHC Aebersold Ruedi R MacInnes Alyson W AW Houtkooper Riekelt H RH
Cell metabolism 20200220 3
Slowing down translation in either the cytosol or the mitochondria is a conserved longevity mechanism. Here, we found a non-interventional natural correlation of mitochondrial and cytosolic ribosomal proteins (RPs) in mouse population genetics, suggesting a translational balance. Inhibiting mitochondrial translation in C. elegans through mrps-5 RNAi repressed cytosolic translation. Transcriptomics integrated with proteomics revealed that this inhibition specifically reduced translational efficie ...[more]