Plasma metabolites associated with colorectal cancer stage: Findings from an international consortium.

ABSTRACT: Colorectal cancer is the second most common cause of cancer-related death globally, with marked differences in prognosis by disease stage at diagnosis. We studied circulating metabolites in relation to disease stage to improve the understanding of metabolic pathways related to colorectal cancer progression. We investigated plasma concentrations of 130 metabolites among 744 Stages I-IV colorectal cancer patients from ongoing cohort studies. Plasma samples, collected at diagnosis, were analyzed with liquid chromatography-mass spectrometry using the Biocrates AbsoluteIDQ™ p180 kit. We assessed associations between metabolite concentrations and stage using multinomial and multivariable logistic regression models. Analyses were adjusted for potential confounders as well as multiple testing usin

SUBMITTER: Geijsen AJMR 

PROVIDER: S-EPMC7216900 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature