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COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer.


ABSTRACT: It is now recognised that a part of the inherited risk of colorectal cancer (CRC) can be explained by the co-inheritance of low-penetrance genetic variants. The accumulated experience to date in identifying these variants has served to highlight difficulties in conducting statistically and methodologically rigorous studies and follow-up analyses. The COGENT (COlorectal cancer GENeTics) consortium includes 20 research groups in Europe, Australia, the Americas, China and Japan. The overarching goal of COGENT is to identify and characterise low-penetrance susceptibility variants for CRC through association-based analyses. In this study, we review the rationale for identifying low-penetrance variants for CRC and our proposed strategy for establishing COGENT.

SUBMITTER: Tomlinson IP 

PROVIDER: S-EPMC2816642 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature

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COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer.

Tomlinson I P M IP   Dunlop M M   Campbell H H   Zanke B B   Gallinger S S   Hudson T T   Koessler T T   Pharoah P D PD   Niittymäki I I   Tuupanen S S   Aaltonen L A LA   Hemminki K K   Lindblom A A   Försti A A   Sieber O O   Lipton L L   van Wezel T T   Morreau H H   Wijnen J T JT   Devilee P P   Matsuda K K   Nakamura Y Y   Castellví-Bel S S   Ruiz-Ponte C C   Castells A A   Carracedo A A   Ho J W C JW   Sham P P   Hofstra R M W RM   Vodicka P P   Brenner H H   Hampe J J   Schafmayer C C   Tepel J J   Schreiber S S   Völzke H H   Lerch M M MM   Schmidt C A CA   Buch S S   Moreno V V   Villanueva C M CM   Peterlongo P P   Radice P P   Echeverry M M MM   Velez A A   Carvajal-Carmona L L   Scott R R   Penegar S S   Broderick P P   Tenesa A A   Houlston R S RS  

British journal of cancer 20091117 2


It is now recognised that a part of the inherited risk of colorectal cancer (CRC) can be explained by the co-inheritance of low-penetrance genetic variants. The accumulated experience to date in identifying these variants has served to highlight difficulties in conducting statistically and methodologically rigorous studies and follow-up analyses. The COGENT (COlorectal cancer GENeTics) consortium includes 20 research groups in Europe, Australia, the Americas, China and Japan. The overarching goa  ...[more]

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