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TNF-? - 308?G/A and IFN-? + 874 A/T gene polymorphisms in Saudi patients with cutaneous leishmaniasis.

ABSTRACT: BACKGROUND:Cutaneous leishmaniasis (CL) is well linked with immunogenetic factors. This study was undertaken to test the association of TNF-??-?308 and IFN-??+?874 gene polymorphisms with the susceptibility of Leishmania (L) species among CL patients in central region of Saudi Arabia. METHODS:This is a case-control study involved 169 Saudi subjects with different L. species and 199 healthy controls from central region of Saudi Arabia. All subjects were characterized by TNF-??-?308?G/A and IFN-??+?874 A/T gene polymorphisms using PCR. RESULTS:Evaluation of genotyping and allelic frequency of TNF-??-?308?G/A in different L. species showed no significant association compared to controls (p?>?0.05). Except, in cases of L. tropica that showed significantly higher TNF-??-?308 A versus G allele frequency (p?=?0.0004). Evaluation of genotyping of IFN-??+?874 (TT versus AA+AT recessive) and allelic frequency of IFN-??+?874 (T versus A) showed significant higher in L. major and also in total CL cases as compared to healthy controls (p?

SUBMITTER: Ahmed AA 

PROVIDER: S-EPMC7218653 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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TNF-α - 308 G/A and IFN-γ + 874 A/T gene polymorphisms in Saudi patients with cutaneous leishmaniasis.

Ahmed Ahmed A AA   Rasheed Zafar Z   Salem Tarek T   Al-Dhubaibi Mohammed S MS   Al Robaee Ahmad A AA   Alzolibani Abdullateef A AA  

BMC medical genetics 20200513 1

<h4>Background</h4>Cutaneous leishmaniasis (CL) is well linked with immunogenetic factors. This study was undertaken to test the association of TNF-α - 308 and IFN-γ + 874 gene polymorphisms with the susceptibility of Leishmania (L) species among CL patients in central region of Saudi Arabia.<h4>Methods</h4>This is a case-control study involved 169 Saudi subjects with different L. species and 199 healthy controls from central region of Saudi Arabia. All subjects were characterized by TNF-α - 308  ...[more]

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