Linker Domains: Why ABC Transporters 'Live in Fragments no Longer'.
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ABSTRACT:
SUBMITTER: Ford RC
PROVIDER: S-EPMC7219603 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Publications
Linker Domains: Why ABC Transporters 'Live in Fragments no Longer'.
Ford Robert C RC Marshall-Sabey Dominic D Schuetz John J
Trends in biochemical sciences 20191212 2
ATP-binding cassette (ABC) transporters are membrane proteins present in all kingdoms of life. We have considered the disordered region that connects the N- and C-terminal halves in many eukaryotic ABC transporters, allowing all four consensus functional domains to be linked. The recent availability of structures of ABC transporters containing linker regions has allowed us to identify the start and end points of the connectors as well as hinting at their localisation. We address questions such a ...[more]
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