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Observing Host-Guest Interactions at Molecular Interfaces by Monitoring the Electrochemical Current.

ABSTRACT: Macrocyclic cucurbit[n]uril (CB[n]) molecules have triggered renewed interest because of their outstanding capabilities as host molecules to selectively interact with a wide range of small guest molecules. Here, CB[7]-based host-guest interactions were investigated for a guest-modified nanoelectrode by monitoring the electrochemical current. A ferrocene (Fc)-terminated molecule immobilized on a gold nanoelectrode (GNE) showed suitable affinity with CB[7] when the effective exposing area of the GNE was between 5.3 and 12 ?m2 and the bias applied on the GNE was -500 mV. Monitoring the dynamics of nanoparticles (NPs) on a nanoelectrode provides new insights into the host-guest interactions at molecular interfaces.

SUBMITTER: Ai Q

PROVIDER: S-EPMC7227043 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Observing Host-Guest Interactions at Molecular Interfaces by Monitoring the Electrochemical Current.

Ai Qiushuang Q Jin Lunqiang L Gong Zhengjie Z Liang Feng F

ACS omega 20200430 18

Macrocyclic cucurbit[n]uril (CB[n]) molecules have triggered renewed interest because of their outstanding capabilities as host molecules to selectively interact with a wide range of small guest molecules. Here, CB[7]-based host-guest interactions were investigated for a guest-modified nanoelectrode by monitoring the electrochemical current. A ferrocene (Fc)-terminated molecule immobilized on a gold nanoelectrode (GNE) showed suitable affinity with CB[7] when the effective exposing ...[more]

PMID: 32426616

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