Ontology highlight
ABSTRACT:
SUBMITTER: Smith AAA
PROVIDER: S-EPMC7497526 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Smith Anton A A AAA Gale Emily C EC Roth Gillie A GA Maikawa Caitlin L CL Correa Santiago S Yu Anthony C AC Appel Eric A EA
Biomacromolecules 20200820 9
Cancer immunotherapy can be augmented with toll-like receptor agonist (TLRa) adjuvants, which interact with immune cells to elicit potent immune activation. Despite their potential, use of many TLRa compounds has been limited clinically due to their extreme potency and lack of pharmacokinetic control, causing systemic toxicity from unregulated systemic cytokine release. Herein, we overcome these shortcomings by generating poly(ethylene glycol)-poly(lactic acid) (PEG-PLA) nanoparticles (NPs) pres ...[more]