Ontology highlight
ABSTRACT:
SUBMITTER: Feng J
PROVIDER: S-EPMC7232929 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents 20200518 8
The diaryl ureas are very important fragments in medicinal chemistry. By means of computer-aided design, 1-aryl-3-[4-(pyridin-2-ylmethoxy)phenyl]urea derivatives were designed and synthesized, and evaluated for their antiproliferative activity against A549, HCT-116, PC-3 cancer cell lines, and HL7702 human normal liver cell lines in vitro by using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide colorimetric assay. Most of the target compounds demonstrate significant antiproliferativ ...[more]