Incorporation of frailty estimated by gait speed within MELD-Na and the predictive potential for mortality in cirrhosis.

ABSTRACT:

Background

The 5 m gait speed (5MGS), a simple and reliable performance metric and surrogate indicator of frailty, consistently predicts adverse events in elders. Additionally, MELD-Na (model for end-stage liver disease-sodium) scores fail to capture nutritional and functional decline of cirrhotic patients that may confer excess mortality. We hypothesized that 5MGS might be associated with all-cause mortality, and that inclusion of frailty assessment within MELD-Na could improve the prediction of mortality in cirrhosis.

Methods

5MGS was measured at baseline in 113 hospitalized cirrhotic patients. Survival status over 2 years and cirrhosis-related complications were recorded. We evaluated the prognostic value of 5MGS (as a continuous variable and as a dichotomous variable). T

SUBMITTER: Deng Y 

PROVIDER: S-EPMC7238306 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature