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Renal Clearable Gold Nanoparticle-Functionalized Silk Film for in vivo Fluorescent Temperature Mapping.


ABSTRACT: Implantable optical sensing devices that can continuously monitor physiological temperature changes hold great potential toward applications in healthcare and medical field. Here, we present a conceptual foundation for the design of biocompatible temperature sensing device by integrating renal clearable luminescent gold nanoparticles (AuNPs) with silk film (AuNPs-SF). We found that the AuNPs display strong temperature dependence in both near-IR fluorescence intensity and lifetime over a large temperature range (10-60°C), with a fluorescence intensity sensitivity of 1.72%/°C and lifetime sensitivity of 0.09 ?s/°C. When integrated, the AuNPs with biocompatible silk film are implanted in the dorsal region of mice. The fluorescence imaging of the AuNPs-SF in the body shows a linear relationship between the average fluorescence intensity and temperature. More importantly, <3.68% ID gold are left in the body, and no adverse effect is observed for 8 weeks. This AuNPs-SF can be potentially used as a flexible, biocompatible, and implantable sensing device for in vivo temperature mapping.

SUBMITTER: Hua W 

PROVIDER: S-EPMC7243850 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Renal Clearable Gold Nanoparticle-Functionalized Silk Film for <i>in vivo</i> Fluorescent Temperature Mapping.

Hua Wei W   Mao Yusheng Y   Zhang Jinzhu J   Liu Lang L   Zhang Guolin G   Yang Shengyang S   Boyer Daniel D   Zhou Chen C   Zheng Fenfen F   Sun Shasha S   Lin Shengling S  

Frontiers in chemistry 20200515


Implantable optical sensing devices that can continuously monitor physiological temperature changes hold great potential toward applications in healthcare and medical field. Here, we present a conceptual foundation for the design of biocompatible temperature sensing device by integrating renal clearable luminescent gold nanoparticles (AuNPs) with silk film (AuNPs-SF). We found that the AuNPs display strong temperature dependence in both near-IR fluorescence intensity and lifetime over a large te  ...[more]

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