Ontology highlight
ABSTRACT:
SUBMITTER: Loynachan CN
PROVIDER: S-EPMC7045344 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Loynachan Colleen N CN Soleimany Ava P AP Dudani Jaideep S JS Lin Yiyang Y Najer Adrian A Bekdemir Ahmet A Chen Qu Q Bhatia Sangeeta N SN Stevens Molly M MM
Nature nanotechnology 20190902 9
Ultrasmall gold nanoclusters (AuNCs) have emerged as agile probes for in vivo imaging, as they exhibit exceptional tumour accumulation and efficient renal clearance properties. However, their intrinsic catalytic activity, which can enable an increased detection sensitivity, has yet to be explored for in vivo sensing. By exploiting the peroxidase-mimicking activity of AuNCs and the precise nanometre-size filtration of the kidney, we designed multifunctional protease nanosensors that respond to di ...[more]