Ontology highlight
ABSTRACT:
SUBMITTER: Romereim SM
PROVIDER: S-EPMC7244214 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Romereim Sarah M SM Johnston Caleb A CA Redwine Adan L AL Wachs Rebecca A RA
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20191219 5
Pain originating from an intervertebral disc (discogenic pain) is a major source of chronic low back pain. Pathological innervation of the disc by pain-sensing nerve fibers is thought to be a key component of discogenic pain, so treatment with biomaterials that have the ability to inhibit neurite growth will greatly benefit novel disc therapeutics. Currently, disc therapeutic biomaterials are rarely screened for their ability to modulate nerve growth, mainly due to a lack of models to screen neu ...[more]