Can NF-?B Be Considered a Valid Drug Target in Neoplastic Diseases? Our Point of View.
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ABSTRACT:
SUBMITTER: Labbozzetta M
PROVIDER: S-EPMC7246796 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Publications
Can NF-κB Be Considered a Valid Drug Target in Neoplastic Diseases? Our Point of View.
Labbozzetta Manuela M Notarbartolo Monica M Poma Paola P
International journal of molecular sciences 20200427 9
Multidrug resistance (MDR), of the innate and acquired types, is one of major problems in treating tumor diseases with a good chance of success. In this review, we examine the key role of nuclear factor-kappa B (NF-κB) to induce MDR in three tumor models characterized precisely by innate or acquired MDR, in particular triple negative breast cancer (TNBC), hepatocellular carcinoma (HCC), and acute myeloid leukemia (AML). We also present different pharmacological approaches that our group have emp ...[more]
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