Ontology highlight
ABSTRACT:
SUBMITTER: Lei MZ
PROVIDER: S-EPMC7256045 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Lei Ming-Zhu MZ Li Xu-Xu XX Zhang Ye Y Li Jin-Tao JT Zhang Fan F Wang Yi-Ping YP Yin Miao M Qu Jia J Lei Qun-Ying QY
Signal transduction and targeted therapy 20200529 1
Pancreatic ductal adenocarcinoma (PDAC) is well-known for inefficient early diagnosis, with most patients diagnosed at advanced stages. Increasing evidence indicates that elevated plasma levels of branched-chain amino acids (BCAAs) are associated with an increased risk of pancreatic cancer. Branched-chain amino acid transaminase 2 (BCAT2) is an important enzyme in BCAA catabolism that reversibly catalyzes the initial step of BCAA degradation to branched-chain acyl-CoA. Here, we show that BCAT2 i ...[more]