Ontology highlight
ABSTRACT:
SUBMITTER: Huckaby JT
PROVIDER: S-EPMC7259474 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Huckaby Justin T JT Parker Christina L CL Jacobs Tim M TM Schaefer Alison A Wadsworth Daniel D Nguyen Alexander A Wang Anting A Newby Jay J Lai Samuel K SK
Angewandte Chemie (International ed. in English) 20190321 17
Mucus represents a major barrier to sustained and targeted drug delivery to mucosal epithelium. Ideal drug carriers should not only rapidly diffuse across mucus, but also bind the epithelium. Unfortunately, ligand-conjugated particles often exhibit poor penetration across mucus. In this work, we explored a two-step "pretargeting" approach through engineering a bispecific antibody that binds both cell-surface ICAM-1 and polyethylene glycol (PEG) on the surface of nanoparticles, thereby effectivel ...[more]