Ontology highlight
ABSTRACT:
SUBMITTER: Yarchoan M
PROVIDER: S-EPMC7259524 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Yarchoan Mark M Ho Won Jin WJ Mohan Aditya A Shah Yajas Y Vithayathil Teena T Leatherman James J Dennison Lauren L Zaidi Neeha N Ganguly Sudipto S Woolman Skylar S Cruz Kayla K Armstrong Todd D TD Jaffee Elizabeth M EM
JCI insight 20200521 10
Immunotherapies that modulate T cell function have been firmly established as a pillar of cancer therapy, whereas the potential for B cells in the antitumor immune response is less established. B cell-activating factor (BAFF) is a B cell-activating cytokine belonging to the TNF ligand family that has been associated with autoimmunity, but little is known about its effects on cancer immunity. We find that BAFF upregulates multiple B cell costimulatory molecules; augments IL-12a expression, consis ...[more]