Ontology highlight
ABSTRACT:
SUBMITTER: Pan H
PROVIDER: S-EPMC7261166 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Pan Hai H Jin Miao M Ghadiyaram Ashwin A Kaur Parminder P Miller Henry E HE Ta Hai Minh HM Liu Ming M Fan Yanlin Y Mahn Chelsea C Gorthi Aparna A You Changjiang C Piehler Jacob J Riehn Robert R Bishop Alexander J R AJR Tao Yizhi Jane YJ Wang Hong H
Nucleic acids research 20200601 10
Cohesin SA1 (STAG1) and SA2 (STAG2) are key components of the cohesin complex. Previous studies have highlighted the unique contributions by SA1 and SA2 to 3D chromatin organization, DNA replication fork progression, and DNA double-strand break (DSB) repair. Recently, we discovered that cohesin SA1 and SA2 are DNA binding proteins. Given the recently discovered link between SA2 and RNA-mediated biological pathways, we investigated whether or not SA1 and SA2 directly bind to RNA using a combinati ...[more]