Ontology highlight
ABSTRACT:
SUBMITTER: Alexander KM
PROVIDER: S-EPMC5832446 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Pharmacology & therapeutics 20170622
Amyloidosis refers to a range of protein misfolding disorders that can cause organ dysfunction through progressive fibril deposition. Cardiac involvement often leads to significant morbidity and mortality and increasingly has been recognized as an important cause of heart failure. The two main forms of cardiac amyloidosis, light chain (AL) and transthyretin (ATTR) amyloidosis, have distinct mechanisms of pathogenesis. Recent insights have led to the development of novel pharmacotherapies with th ...[more]