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Modulation of amygdala reactivity following rapidly acting interventions for major depression.


ABSTRACT: Electroconvulsive therapy (ECT) and ketamine treatment both induce rapidly acting antidepressant effects in patients with major depressive disorder unresponsive to standard treatments, yet their specific impact on emotion processing is unknown. Here, we examined the neural underpinnings of emotion processing within and across patients (N =?44) receiving either ECT (N =?17, mean age: 36.8, 11.0 SD) or repeated subanesthetic (0.5?mg/kg) intravenous ketamine therapy (N =?27, mean age: 37.3, 10.8 SD) using a naturalistic study design. MRI and clinical data were collected before (TP1) and after treatment (TP2); healthy controls (N =?31, mean age: 34.5, 13.5 SD) completed one MRI session (TP1). An fMRI face-matching task probed negative- and positive-valence systems. Whole-brain analysis, comparing neurofunctional changes within and across treatment groups, targeted brain regions involved in emotional facial processing, and included regions-of-interest analysis of amygdala responsivity. Main findings revealed a decrease in amygdalar reactivity after both ECT and ketamine for positive and negative emotional face processing (p

SUBMITTER: Loureiro JRA 

PROVIDER: S-EPMC7268016 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Modulation of amygdala reactivity following rapidly acting interventions for major depression.

Loureiro Joana R A JRA   Leaver Amber A   Vasavada Megha M   Sahib Ashish K AK   Kubicki Antoni A   Joshi Shantanu S   Woods Roger P RP   Wade Benjamin B   Congdon Eliza E   Espinoza Randall R   Narr Katherine L KL  

Human brain mapping 20200301 7


Electroconvulsive therapy (ECT) and ketamine treatment both induce rapidly acting antidepressant effects in patients with major depressive disorder unresponsive to standard treatments, yet their specific impact on emotion processing is unknown. Here, we examined the neural underpinnings of emotion processing within and across patients (N = 44) receiving either ECT (N = 17, mean age: 36.8, 11.0 SD) or repeated subanesthetic (0.5 mg/kg) intravenous ketamine therapy (N = 27, mean age: 37.3, 10.8 SD  ...[more]

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