Ontology highlight
ABSTRACT: Background/aim
Interleukin-16 has been reported to exhibit tumoricidal effects, however, the contribution of IL-16 genotypes to lung cancer is still largely unrevealed. This study aimed at investigating whether IL-16 genotypes contribute to lung cancer susceptibility.Materials and methods
IL-16 rs4778889, rs11556218, and rs4072111 genotypic characteristics were determined among 358 lung cancer patients and 716 controls via the polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) methodology.Results
The highlight finding is that the distributions of genotypic (p=8.6E-10) and allelic (p=0.0001) frequencies of IL-16 rs11556218 was significantly different between cases and controls. In detail, the frequencies of IL-16 rs11556218 heterozygous variant TG and homozygous variant GG were 36.6 and 7.3% among the lung cancer patients, significantly higher than those among the controls (22.5% and 2.6%). On the other way, no difference was observed regarding IL-16 rs4778889 or IL-16 rs4072111.Conclusion
The present study indicates IL-16 rs11556218 G allele is significantly associated with increased Taiwan lung cancer risk.
SUBMITTER: Wu MF
PROVIDER: S-EPMC7279827 | biostudies-literature | 2020 May-Jun
REPOSITORIES: biostudies-literature
Wu Meng-Feng MF Wang Yun-Chi YC Shen Te-Chun TC Chang Wen-Shin WS Li Hsin-Ting HT Liao Cheng-Hsi CH Gong Chi-Li CL Wang Zhi-Hong ZH Tsai Chia-Wen CW Hsia Te-Chun TC Bau DA-Tian DT
In vivo (Athens, Greece) 20200501 3
<h4>Background/aim</h4>Interleukin-16 has been reported to exhibit tumoricidal effects, however, the contribution of IL-16 genotypes to lung cancer is still largely unrevealed. This study aimed at investigating whether IL-16 genotypes contribute to lung cancer susceptibility.<h4>Materials and methods</h4>IL-16 rs4778889, rs11556218, and rs4072111 genotypic characteristics were determined among 358 lung cancer patients and 716 controls via the polymerase chain reaction-based restriction fragment ...[more]