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Magnetic and near-infrared derived heating characteristics of dimercaptosuccinic acid coated uniform Fe@Fe₃O₄ core-shell nanoparticles.

ABSTRACT: Among the number of hyperthermia materials, magnetic nanoparticles have received much attention. In this work, we studied the heating characteristics of uniform Fe@Fe₃O₄ core-shell nanoparticle under near-infrared laser irradiation and external AC magnetic field applying. The Fe@Fe₃O₄ core-shell nanoparticles were prepared by thermal decomposition of iron pentacarbonyl and followed by controlled oxidation. The prepared uniform particles were further coated with dimercaptosuccinic acid to make them well dispersed in water. Near-infrared derived photothermal study of solutions containing a different concentration of the core-shell nanoparticles was made by using 808 nm laser Source. Additionally, magnetic hyperthermia ability of the Fe@Fe₃O₄ nanoparticle at 150 kHz and various oersted (140-180 Oe) condition was systemically characterized. The Fe@Fe₃O₄ nanoparticles which exhibited effective photo and magnetic hyperthermia are expected to be used in biomedical application.

SUBMITTER: Koo C

PROVIDER: S-EPMC7280462 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Magnetic and near-infrared derived heating characteristics of dimercaptosuccinic acid coated uniform Fe@Fe3O4 core-shell nanoparticles.

Koo Changhyuk C Hong Hwichan H Im Pyung Won PW Kim Hoonsub H Lee Chaedong C Jin Xuanzhen X Yan Bingyi B Lee Wooseung W Im Hyung-Jun HJ Paek Sun Ha SH Piao Yuanzhe Y

Nano convergence 20200608 1

Among the number of hyperthermia materials, magnetic nanoparticles have received much attention. In this work, we studied the heating characteristics of uniform Fe@Fe3O4 core-shell nanoparticle under near-infrared laser irradiation and external AC magnetic field applying. The Fe@Fe3O4 core-shell nanoparticles were prepared by thermal decomposition of iron pentacarbonyl and followed by controlled oxidation. The prepared uniform particles were further co ...[more]

PMID: 32514813

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Project description:Recently, the functionalization of nanoparticles, either within themselves or on the outer surface and its application in medicine, turned out to be the ultimate goal of nanotechnology. By providing these nanoparticles with chemical functional groups, one can force the nanoparticles to target the markers of the particular diseases or to measure the quantity and distribution of various intracellular species. In this paper, we report our development of a pH-responsive nanocomposite based on lanthanide-doped upconverting nanoparticles (UCNPs). Through multiphoton absorption and energy migration between spatially separated Nd3+, Yb3+, and Tm3+ in a three-layered NaYF4 host coated with FITC (fluorescein-5-isothiocyanate), this nanocomposite can measure the pH with high sensitivity. The fundamental acidity measurement is based on the pH-dependent equilibrium of the bright and dark states of FITC. The tremendous advantages of this system, regarding the pH measurement, come from the fact that the versatility of UCNP-imaging can fully be exploited. This includes the fact that (a) the optical wavelengths for the sensitization (980 nm and/or 808 nm) and the emission bands (UV, visible) are well separated, (b) the spectral overlap between FITC (absorption) and Tm3+ (emission) is substantially high, (c) there is no background signal due to the near-infrared laser, and (d) the signals are consistent regardless of the fluctuations by monitoring the ratio of blue band with respect to the unaffected self-reference (red and near-infrared bands). Moreover, the double shell structure is obviously superior to the core-shell structure in that it enhances the spectral separation between the sensitizer and the emitter in the upconversion process, inhibiting any unnecessary contamination in the spectra. Finally, it is noteworthy that Yb3+ plays crucial roles as a sensitizer at 980 nm excitation and a bridge above which 808 nm excitation migrates from Nd3+ to Tm3+ via the Yb3+ excited state.

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Magnetic and near-infrared derived heating characteristics of dimercaptosuccinic acid coated uniform Fe@Fe₃O₄ core-shell nanoparticles.

Publications

Magnetic and near-infrared derived heating characteristics of dimercaptosuccinic acid coated uniform Fe@Fe<sub>3</sub>O<sub>4</sub> core-shell nanoparticles.

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