MicroRNA-513a-3p regulates colorectal cancer cell metabolism via targeting hexokinase 2.
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ABSTRACT:
SUBMITTER: Li C
PROVIDER: S-EPMC7282190 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Publications
MicroRNA-513a-3p regulates colorectal cancer cell metabolism via targeting hexokinase 2.
Li Chen C Yu Zhijin Z Ye Jinpeng J
Experimental and therapeutic medicine 20200507 1
Disruption of cell metabolism is a hallmark of cancer cells. Accumulating evidence suggests that microRNAs (miRNAs/miRs) are involved in almost all physiological and pathological processes. The aberrant expression of miRNAs induces metabolic reprogramming in cancer cells and thus, promotes proliferation. In the current study, miR-513a-3p was identified as a significantly downregulated miRNA in colorectal cancer cells and tumors. Overexpression of miR-513a-3p in colorectal cancer cells inhibited ...[more]
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