Ontology highlight
ABSTRACT:
SUBMITTER: Milordini G
PROVIDER: S-EPMC7284065 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Milordini Giulia G Zacco Elsa E Percival Matthew M Puglisi Rita R Dal Piaz Fabrizio F Temussi Pierandrea P Pastore Annalisa A
Frontiers in molecular biosciences 20200603
Epidemiological evidence shows an increased risk for developing Alzheimer's disease in people affected by diabetes, a pathology associated with increased hyperglycemia. A potential factor that could explain this link could be the role that sugars may play in both diseases under the form of glycation. Contrary to glycosylation, glycation is an enzyme-free reaction that leads to formation of toxic advanced glycation end-products (AGEs). In diabetes, the islet amyloid polypeptide (IAPP or amylin) i ...[more]