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Fat Oxidation Kinetics Is Related to Muscle Deoxygenation Kinetics During Exercise.


ABSTRACT: Purpose:The present study aimed to determine whether whole-body fat oxidation and muscle deoxygenation kinetics parameters during exercise were related in individuals with different aerobic fitness levels. Methods:Eleven cyclists [peak oxygen uptake ( V.O2?p?e?a?k ): 64.9 ± 3.9 mL?kg-1?min-1] and 11 active individuals ( V.O2?p?e?a?k : 49.1 ± 7.4 mL?kg-1?min-1) performed a maximal incremental cycling test to determine V.O2?p?e?a?k and a submaximal incremental cycling test to assess whole-body fat oxidation using indirect calorimetry and muscle deoxygenation kinetics of the vastus lateralis (VL) using near-infrared spectroscopy (NIRS). A sinusoidal (SIN) model was used to characterize fat oxidation kinetics and to determine the intensity (Fatmax) eliciting maximal fat oxidation (MFO). The muscle deoxygenation response was fitted with a double linear model. The slope of the first parts of the kinetics (a 1) and the breakpoint ([HHb]BP) were determined. Results:MFO (p = 0.01) and absolute fat oxidation rates between 20 and 65% V.O2?p?e?a?k were higher in cyclists than in active participants (p < 0.05), while Fatmax occurred at a higher absolute exercise intensity (p = 0.01). a 1 was lower in cyclists (p = 0.02) and [HHb]BP occurred at a higher absolute intensity (p < 0.001) than in active individuals. V.O2?p?e?a?k was strongly correlated with MFO, Fatmax, and [HHb]BP (r = 0.65-0.88, p ? 0.001). MFO and Fatmax were both correlated with [HHb]BP (r = 0.66, p = 0.01 and r = 0.68, p < 0.001, respectively) and tended to be negatively correlated with a 1 (r = -0.41, p = 0.06 for both). Conclusion:This study showed that whole-body fat oxidation and muscle deoxygenation kinetics were both related to aerobic fitness and that a relationship between the two kinetics exists. Individuals with greater aerobic fitness may have a delayed reliance on glycolytic metabolism at higher exercise intensities because of a longer maintained balance between O2 delivery and consumption supporting higher fat oxidation rates.

SUBMITTER: Zurbuchen A 

PROVIDER: S-EPMC7289152 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Fat Oxidation Kinetics Is Related to Muscle Deoxygenation Kinetics During Exercise.

Zurbuchen Anouck A   Lanzi Stefano S   Voirol Ludovic L   Trindade Cybele Barboza CB   Gojanovic Boris B   Kayser Bengt B   Bourdillon Nicolas N   Chenevière Xavier X   Malatesta Davide D  

Frontiers in physiology 20200604


<h4>Purpose</h4>The present study aimed to determine whether whole-body fat oxidation and muscle deoxygenation kinetics parameters during exercise were related in individuals with different aerobic fitness levels.<h4>Methods</h4>Eleven cyclists [peak oxygen uptake ( V . O 2 ⁢ p ⁢ e ⁢ a ⁢ k ): 64.9 ± 3.9 mL⋅kg<sup>-1</sup>⋅min<sup>-1</sup>] and 11 active individuals ( V . O 2 ⁢ p ⁢ e ⁢ a ⁢ k : 49.1 ± 7.4 mL⋅kg<sup>-1</sup>⋅min<sup>-1</sup>) performed a maximal incremental cycling test t  ...[more]

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