Ontology highlight
ABSTRACT:
SUBMITTER: Naffa R
PROVIDER: S-EPMC7290426 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Naffa Randa R Vogel Lisa L Hegedűs Luca L Pászty Katalin K Tóth Sarolta S Kelemen Kornélia K Singh Neha N Reményi Attila A Kállay Enikő E Cserepes Mihály M Tóvári József J Grusch Michael M Enyedi Ágnes Á
Cells 20200513 5
Metastatic melanoma is the most aggressive type of skin cancer. Previously, we identified the plasma membrane Ca<sup>2+</sup> pump isoform 4b (PMCA4b or <i>ATP2B4</i>) as a putative metastasis suppressor in BRAF mutant melanoma cells. Metastasis suppressors are often downregulated in cancer, therefore, it is important to identify the pathways involved in their degradation. Here, we studied the role of p38 MAPK in PMCA4b degradation and its effect on melanoma metastasis. We found that activation ...[more]