Ontology highlight
ABSTRACT:
SUBMITTER: Garcia-Valtanen P
PROVIDER: S-EPMC7290755 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Garcia-Valtanen Pablo P Guzman-Genuino Ruth Marian RM Hayball John D JD Diener Kerrilyn R KR
Viruses 20200522 5
White adipose tissue (WAT) produces interleukin-10 and other immune suppressors in response to pathogen-associated molecular patterns (PAMPs). It also homes a subset of B-cells specialized in the production of IL-10, referred to as regulatory B-cells. We investigated whether viral stimuli, polyinosinic: polycytidylic acid (poly(I:C)) or whole replicative murine cytomegalovirus (MCMV), could stimulate the expression of IL-10 in murine WAT using in vivo and ex vivo approaches. Our results showed t ...[more]