Structural Insights into the Activation of mTORC1 on the Lysosomal Surface.
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ABSTRACT:
SUBMITTER: Park JH
PROVIDER: S-EPMC7297057 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Publications
Structural Insights into the Activation of mTORC1 on the Lysosomal Surface.
Park Jin H JH Lee Gina G Blenis John J
Trends in biochemical sciences 20200227 5
Using cryo-electron microscopy and molecular characterization, David Sabatini and colleagues provide crucial new insights that validate and expand their model of how amino acids are sensed and signal at the lysosome to activate mechanistic target of rapamycin complex 1 (mTORC1) and cell growth-regulating processes. This work also reveals new therapeutic opportunities for mTORC1-driven diseases. ...[more]
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