Ontology highlight
ABSTRACT:
SUBMITTER: Rogala KB
PROVIDER: S-EPMC7176403 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Rogala Kacper B KB Gu Xin X Kedir Jibril F JF Abu-Remaileh Monther M Bianchi Laura F LF Bottino Alexia M S AMS Dueholm Rikke R Niehaus Anna A Overwijn Daan D Fils Ange-Célia Priso AP Zhou Sherry X SX Leary Daniel D Laqtom Nouf N NN Brignole Edward J EJ Sabatini David M DM
Science (New York, N.Y.) 20191010 6464
The mTORC1 (mechanistic target of rapamycin complex 1) protein kinase regulates growth in response to nutrients and growth factors. Nutrients promote its translocation to the lysosomal surface, where its Raptor subunit interacts with the Rag guanosine triphosphatase (GTPase)-Ragulator complex. Nutrients switch the heterodimeric Rag GTPases among four different nucleotide-binding states, only one of which (RagA/B•GTP-RagC/D•GDP) permits mTORC1 association. We used cryo-electron microscopy to dete ...[more]