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Increased assessment of HER2 in metastatic gastroesophageal cancer patients: a nationwide population-based cohort study.

ABSTRACT: BACKGROUND:Addition of trastuzumab to first-line palliative chemotherapy in gastroesophageal cancer patients with HER2 overexpression has shown to improve survival. Real-world data on HER2 assessment and administration of trastuzumab are lacking. The aim of this study was to assess HER2 testing, trastuzumab administration, and overall survival (OS) in a nationwide cohort of metastatic gastroesophageal cancer patients. METHODS:Data of patients with synchronous metastatic gastroesophageal adenocarcinoma diagnosed in 2010-2016 that received palliative systemic treatment (n?=?2846) were collected from the Netherlands Cancer Registry and Dutch Pathology Registry. The ToGA trial criteria were used to determine HER2 overexpression. Proportions of HER2 tested patients were analyzed between hospital volume categories using Chi-square tests, and over time using trend analysis. OS was tested using the Kaplan Meier method with log rank test. RESULTS:HER2 assessment increased annually, from 18% in 2010 to 88% in 2016 (P?

SUBMITTER: Dijksterhuis WPM

PROVIDER: S-EPMC7305095 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Increased assessment of HER2 in metastatic gastroesophageal cancer patients: a nationwide population-based cohort study.

Dijksterhuis Willemieke P M WPM Verhoeven Rob H A RHA Meijer Sybren L SL Slingerland Marije M Haj Mohammad Nadia N de Vos-Geelen Judith J Beerepoot Laurens V LV van Voorthuizen Theo T Creemers Geert-Jan GJ van Oijen Martijn G H MGH van Laarhoven Hanneke W M HWM

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 20200111 4

<h4>Background</h4>Addition of trastuzumab to first-line palliative chemotherapy in gastroesophageal cancer patients with HER2 overexpression has shown to improve survival. Real-world data on HER2 assessment and administration of trastuzumab are lacking. The aim of this study was to assess HER2 testing, trastuzumab administration, and overall survival (OS) in a nationwide cohort of metastatic gastroesophageal cancer patients.<h4>Methods</h4>Data of patients with synchronous metastatic gastroesop ...[more]

PMID: 31927675

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Project description:BackgroundTuberculosis (TB) presents a global threat in the world and the lung is the frequent site of metastatic focus. A previous study demonstrated that TB might increase primary lung cancer risk by two-fold for more than 20 years after the TB diagnosis. However, no large-scale study has evaluated the risk of TB and secondary lung cancer. Thus, we evaluated the risk of secondary lung cancer in patients with or without tuberculosis (TB) using a nationwide population-based dataset.MethodsIn a cohort study of 1,936,512 individuals, we selected 6934 patients among patients with primary cancer and TB infection, based on the International Classification of Disease (ICD-p-CM) codes 010-011 from 2000 to 2015. The control cohort comprised 13,868 randomly selected, propensity-matched patients (by age, gender, and index date) without TB exposure. Using this adjusted date, a possible association between TB and the risk of developing secondary lung cancer was estimated using a Cox proportional hazards regression model.ResultsDuring the follow-up period, secondary lung cancer was diagnosed in 761 (10.97%) patients with TB and 1263 (9.11%) patients without TB. After adjusting for covariates, the risk of secondary lung cancer was 1.67 times greater among primary cancer in the cohort with TB than in the cohort without TB. Stratification revealed that every comorbidity (including diabetes, hypertension, cirrhosis, congestive heart failure, cardiovascular accident, chronic kidney disease, chronic obstructive pulmonary disease) significantly increased the risk of secondary lung cancer when comparing the TB cohort with the non-TB cohort. Moreover, the primary cancer types (including head and neck, colorectal cancer, soft tissue sarcoma, breast, kidney, and thyroid cancer) had a more significant risk of becoming secondary lung cancer.ConclusionA significant association exists between TB and the subsequent risk for metastasis among primary cancers and comorbidities. Therefore, TB patients should be evaluated for the subsequent risk of secondary lung cancer.

Dataset Information

Increased assessment of HER2 in metastatic gastroesophageal cancer patients: a nationwide population-based cohort study.

Publications

Increased assessment of HER2 in metastatic gastroesophageal cancer patients: a nationwide population-based cohort study.

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