Ontology highlight
ABSTRACT:
SUBMITTER: Lee W
PROVIDER: S-EPMC7305159 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Nature communications 20200619 1
MeCP2 plays a multifaceted role in gene expression regulation and chromatin organization. Interaction between MeCP2 and methylated DNA in the regulation of gene expression is well established. However, the widespread distribution of MeCP2 suggests it has additional interactions with chromatin. Here we demonstrate, by both biochemical and genomic analyses, that MeCP2 directly interacts with nucleosomes and its genomic distribution correlates with that of H3K27me3. In particular, the methyl-CpG-bi ...[more]