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MeCP2 regulates genome-wide gene expression through recognition of H3K27me3

ABSTRACT: MeCP2 regulates genome-wide gene expression through recognition of H3K27me3

PROVIDER: PRJNA504787 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR10009766.fastq.gz	Fastqsanger.gz
	SRR10009767.fastq.gz	Fastqsanger.gz
	SRR10009768.fastq.gz	Fastqsanger.gz
	SRR10009769.fastq.gz	Fastqsanger.gz
	SRR10009770.fastq.gz	Fastqsanger.gz

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MeCP2 regulates genome-wide gene expression through recognition of H3K27me3 [ChIP_human]

Project description:MeCP2 regulates genome-wide gene expression through recognition of H3K27me3 [ChIP_human]

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MeCP2 regulates genome-wide gene expression through recognition of H3K27me3 [ChIP_mouse]

Project description:MeCP2 regulates genome-wide gene expression through recognition of H3K27me3 [ChIP_mouse]

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MeCP2 regulates genome-wide gene expression through recognition of H3K27me3 [NanoString]

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MeCP2 regulates genome-wide gene expression through recognition of H3K27me3 [ChIP, MNase]

Project description:MeCP2 regulates genome-wide gene expression through recognition of H3K27me3 [ChIP, MNase]

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MeCP2 regulates genome-wide gene expression through recognition of H3K27me3 [NanoString]

Project description:MeCP2 plays a multifaceted role in gene expression regulation and chromatin organization. Interaction between MeCP2 and methylated DNA to regulate gene expression is well established. However, the widespread MeCP2 distribution suggests its additional interactions with chromatin. Here we show, by both biochemical and ChIP-seq analyses, that MeCP2 directly binds to nucleosome subunit proteins and is recruited to distinct chromatin regions where H3K27me3 is enriched. We further observed that the impact of MeCP2 on transcriptional changes is correlated with histone post-translational modification patterns. Our findings indicate that MeCP2 can be recruited to genomic loci via indirect binding and that interaction between MeCP2 and histone proteins plays a significant role in gene expression regulation.

2018-11-10 | GSE122365 | GEO

MeCP2 regulates genome-wide gene expression through recognition of H3K27me3 [ChIP_human]

2018-11-10 | GSE122364 | GEO

MeCP2 regulates genome-wide gene expression through recognition of H3K27me3 [ChIP_mouse]

2018-11-10 | GSE122363 | GEO

MeCP2 regulates genome-wide gene expression through recognition of H3K27me3 [ChIP, MNase]

2019-01-25 | GSE125585 | GEO

MeCP2 and H3K27me3 binding in Mecp2-knockout and MECP2-transgenic hippocampus

Project description:MeCP2 globally regulates gene expression in the brain. One example is Growth-differentiation factor 11 (Gdf11), which is down-regulated upon loss of MeCP2 and up-regulated upon gain of MeCP2. To assess if MeCP2 binds near the Gdf11 locus we performed CUT&RUN for MeCP2 in Mecp2-knockout or MECP2-transgenic hippocampus. To assess if a repressive histone modification (H3K27me3) was concordantly changed we profiled H3k27me3 in these same matched tissues.

2023-02-23 | GSE213752 | GEO

MeCP2 regulates gene expression through recognition of H3K27me3.

Project description:MeCP2 plays a multifaceted role in gene expression regulation and chromatin organization. Interaction between MeCP2 and methylated DNA in the regulation of gene expression is well established. However, the widespread distribution of MeCP2 suggests it has additional interactions with chromatin. Here we demonstrate, by both biochemical and genomic analyses, that MeCP2 directly interacts with nucleosomes and its genomic distribution correlates with that of H3K27me3. In particular, the methyl-CpG-binding domain of MeCP2 shows preferential interactions with H3K27me3. We further observe that the impact of MeCP2 on transcriptional changes correlates with histone post-translational modification patterns. Our findings indicate that MeCP2 interacts with genomic loci via binding to DNA as well as histones, and that interaction between MeCP2 and histone proteins plays a key role in gene expression regulation.

| S-EPMC7305159 | biostudies-literature

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