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MeCP2 regulates genome-wide gene expression through recognition of H3K27me3 [ChIP, MNase]

ABSTRACT: MeCP2 regulates genome-wide gene expression through recognition of H3K27me3 [ChIP, MNase]

PROVIDER: PRJNA516876 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR8482540.fastq.gz	Fastqsanger.gz
	SRR8482541.fastq.gz	Fastqsanger.gz
	SRR8482542.fastq.gz	Fastqsanger.gz
	SRR8482543.fastq.gz	Fastqsanger.gz
	SRR8482544.fastq.gz	Fastqsanger.gz

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MeCP2 regulates genome-wide gene expression through recognition of H3K27me3 [ChIP, MNase]

Project description:MeCP2 plays a multifaceted role in gene expression regulation and chromatin organization. Interaction between MeCP2 and methylated DNA to regulate gene expression is well established. However, the widespread MeCP2 distribution suggests its additional interactions with chromatin. Here we show, by both biochemical and ChIP-seq analyses, that MeCP2 directly binds to nucleosome subunit proteins and is recruited to distinct chromatin regions where H3K27me3 is enriched. We further observed that the impact of MeCP2 on transcriptional changes is correlated with histone post-translational modification patterns. Our findings indicate that MeCP2 can be recruited to genomic loci via indirect binding and that interaction between MeCP2 and histone proteins plays a significant role in gene expression regulation.

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MeCP2 regulates gene expression through recognition of H3K27me3.

Project description:MeCP2 plays a multifaceted role in gene expression regulation and chromatin organization. Interaction between MeCP2 and methylated DNA in the regulation of gene expression is well established. However, the widespread distribution of MeCP2 suggests it has additional interactions with chromatin. Here we demonstrate, by both biochemical and genomic analyses, that MeCP2 directly interacts with nucleosomes and its genomic distribution correlates with that of H3K27me3. In particular, the methyl-CpG-binding domain of MeCP2 shows preferential interactions with H3K27me3. We further observe that the impact of MeCP2 on transcriptional changes correlates with histone post-translational modification patterns. Our findings indicate that MeCP2 interacts with genomic loci via binding to DNA as well as histones, and that interaction between MeCP2 and histone proteins plays a key role in gene expression regulation.

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