Ontology highlight
ABSTRACT:
SUBMITTER: Vardaxis I
PROVIDER: S-EPMC7308020 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Vardaxis Ioannis I Drabløs Finn F Rye Morten B MB Lindqvist Bo Henry BH
Biostatistics (Oxford, England) 20200701 3
We present model-based analysis for ChIA-PET (MACPET), which analyzes paired-end read sequences provided by ChIA-PET for finding binding sites of a protein of interest. MACPET uses information from both tags of each PET and searches for binding sites in a two-dimensional space, while taking into account different noise levels in different genomic regions. MACPET shows favorable results compared with MACS in terms of motif occurrence and spatial resolution. Furthermore, significant binding sites ...[more]