Immunomodulation of NK Cells by Ionizing Radiation.
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ABSTRACT:
SUBMITTER: Chen J
PROVIDER: S-EPMC7308459 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Immunomodulation of NK Cells by Ionizing Radiation.
Chen Jiarui J Liu Xingyu X Zeng Zihang Z Li Jiali J Luo Yuan Y Sun Wenjie W Gong Yan Y Zhang Junhong J Wu Qiuji Q Xie Conghua C
Frontiers in oncology 20200616
Natural killer (NK) cells play a critical role in the antitumor immunity. Ionizing radiation (IR) has a pronounced effect on modifying NK cell biology, while the molecular mechanisms remain elusive. In this review, we briefly introduce the anti-tumor activity of NK cells and summarize the impact of IR on NK cells both directly and indirectly. On one hand, low-dose ionizing radiation (LDIR) activates NK functions while high-dose ionizing radiation (HDIR) is likely to partially impair NK functions ...[more]
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