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The Emerging Role of Innate Immunity in Chronic Kidney Diseases.

ABSTRACT: Renal fibrosis is a common fate of chronic kidney diseases. Emerging studies suggest that unsolved inflammation will progressively transit into tissue fibrosis that finally results in an irreversible end-stage renal disease (ESRD). Renal inflammation recruits and activates immunocytes, which largely promotes tissue scarring of the diseased kidney. Importantly, studies have suggested a crucial role of innate immunity in the pathologic basis of kidney diseases. This review provides an update of both clinical and experimental information, focused on how innate immune signaling contributes to renal fibrogenesis. A better understanding of the underlying mechanisms may uncover a novel therapeutic strategy for ESRD.

SUBMITTER: Tang PC

PROVIDER: S-EPMC7312694 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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The Emerging Role of Innate Immunity in Chronic Kidney Diseases.

Tang Philip Chiu-Tsun PC Zhang Ying-Ying YY Chan Max Kam-Kwan MK Lam Winson Wing-Yin WW Chung Jeff Yat-Fai JY Kang Wei W To Ka-Fai KF Lan Hui-Yao HY Tang Patrick Ming-Kuen PM

International journal of molecular sciences 20200604 11

Renal fibrosis is a common fate of chronic kidney diseases. Emerging studies suggest that unsolved inflammation will progressively transit into tissue fibrosis that finally results in an irreversible end-stage renal disease (ESRD). Renal inflammation recruits and activates immunocytes, which largely promotes tissue scarring of the diseased kidney. Importantly, studies have suggested a crucial role of innate immunity in the pathologic basis of kidney diseases. This review provides an update of bo ...[more]

PMID: 32512831

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