Ontology highlight
ABSTRACT:
SUBMITTER: Karlsson E
PROVIDER: S-EPMC7314397 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Karlsson Elin E Lindberg Amanda A Andersson Eva E Jemth Per P
Protein science : a publication of the Protein Society 20200506 7
The interaction between the transcriptional coactivators CREBBP/p300 and NCOA is governed by two intrinsically disordered domains called NCBD and CID, respectively. The CID domain emerged within the NCOA protein in deuterostome animals (including vertebrates) after their split from the protostomes (molluscs, worms, and arthropods). However, it has not been clear at which point a high affinity interaction evolved within the deuterostome clade and whether all present-day deuterostome animals have ...[more]